Drug interactions
Chlorpromazine + Metyrosine
Severity: Moderate
Chlorpromazine and Metyrosine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metyrosine depletes catecholamines and can itself cause extrapyramidal symptoms, sedation and depression. Combined with chlorpromazine, a dopamine antagonist, the risk of parkinsonism, dystonia and sedation is higher.
What this interaction means in plain words
Chlorpromazine and Metyrosine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Metyrosine belongs to Miscellaneous.
Why it happens
Additive dopaminergic hypofunction: tyrosine hydroxylase inhibition (metyrosine) plus D2 receptor blockade (chlorpromazine).
What to do
Monitor for extrapyramidal symptoms and excessive sedation. Reduce the dose of either drug or choose an alternative if symptoms develop; labeling advises avoiding the combination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Metyrosine
- Carbidopa-levodopa + Metyrosine Major
- Fluphenazine + Metyrosine Major
- Metoclopramide + Metyrosine Major
- Carbidopa-entacapone-levodopa + Metyrosine Moderate
- Clonidine + Metyrosine Moderate
- Haloperidol + Metyrosine Moderate
Frequently asked questions
Can I take Chlorpromazine with Metyrosine?
MediHelp rates the interaction as moderate. Chlorpromazine and Metyrosine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metyrosine depletes catecholamines and can itself cause extrapyramidal symptoms, sedation and depression. Combined with chlorpromazine, a dopamine antagonist, the risk of parkinsonism, dystonia and sedation is higher.
How serious is the interaction between Chlorpromazine and Metyrosine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms and excessive sedation. Reduce the dose of either drug or choose an alternative if symptoms develop; labeling advises avoiding the combination.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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