Drug interactions
Fluphenazine + Metyrosine
Severity: Major
Fluphenazine and Metyrosine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metyrosine depletes catecholamines and can itself cause extrapyramidal symptoms and sedation. Combined with fluphenazine, these effects are likely to be additive.
What this interaction means in plain words
Fluphenazine and Metyrosine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluphenazine belongs to Central Nervous System; Metyrosine belongs to Miscellaneous.
Why it happens
Additive dopaminergic antagonism and depletion of catecholamines via tyrosine hydroxylase inhibition.
What to do
Avoid the combination if possible, as labeling cautions against phenothiazines with metyrosine. If used together, monitor for extrapyramidal symptoms and sedation and reduce doses as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Metyrosine
- Carbidopa-levodopa + Metyrosine Major
- Metoclopramide + Metyrosine Major
- Carbidopa-entacapone-levodopa + Metyrosine Moderate
- Chlorpromazine + Metyrosine Moderate
- Clonidine + Metyrosine Moderate
- Haloperidol + Metyrosine Moderate
Frequently asked questions
Can I take Fluphenazine with Metyrosine?
MediHelp rates the interaction as major. Fluphenazine and Metyrosine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Metyrosine depletes catecholamines and can itself cause extrapyramidal symptoms and sedation. Combined with fluphenazine, these effects are likely to be additive.
How serious is the interaction between Fluphenazine and Metyrosine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, as labeling cautions against phenothiazines with metyrosine. If used together, monitor for extrapyramidal symptoms and sedation and reduce doses as needed.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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