Drug interactions
Carbidopa-entacapone-levodopa + Sotalol
Severity: Moderate
Carbidopa-entacapone-levodopa and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can cause orthostatic hypotension, and sotalol adds blood pressure and heart rate lowering. Dizziness and falls may result, particularly early in therapy.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Sotalol belongs to Cardiovascular.
Why it happens
Additive hypotensive effects of levodopa and beta-blockade.
What to do
Monitor blood pressure, heart rate and orthostatic symptoms when levodopa is started or changed. Reduce the sotalol dose if symptomatic hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Sotalol?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can cause orthostatic hypotension, and sotalol adds blood pressure and heart rate lowering. Dizziness and falls may result, particularly early in therapy.
How serious is the interaction between Carbidopa-entacapone-levodopa and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and orthostatic symptoms when levodopa is started or changed. Reduce the sotalol dose if symptomatic hypotension or bradycardia occurs.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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