Drug interactions
Carbidopa-levodopa + Ethacrynic acid
Severity: Moderate
Carbidopa-levodopa and Ethacrynic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethacrynic acid is a loop diuretic that causes volume depletion and lowers blood pressure, and levodopa can cause orthostatic hypotension. The combination may produce excessive blood pressure reduction and falls.
What this interaction means in plain words
Carbidopa-levodopa and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-levodopa belongs to Central Nervous System; Ethacrynic acid belongs to Cardiovascular.
Why it happens
Additive hypotensive effects of levodopa and diuretic-induced volume depletion.
What to do
Check orthostatic blood pressure when starting or adjusting either drug. Reduce the diuretic dose or review hydration if hypotension appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Carbidopa-levodopa and Ethacrynic acid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Carbidopa-levodopa
- Carbidopa-levodopa + Isocarboxazid Contraindicated
- Carbidopa-levodopa + Phenelzine Contraindicated
- Carbidopa-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-levodopa Major
- Asenapine + Carbidopa-levodopa Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Carbidopa-levodopa with Ethacrynic acid?
MediHelp rates the interaction as moderate. Carbidopa-levodopa and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethacrynic acid is a loop diuretic that causes volume depletion and lowers blood pressure, and levodopa can cause orthostatic hypotension. The combination may produce excessive blood pressure reduction and falls.
How serious is the interaction between Carbidopa-levodopa and Ethacrynic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check orthostatic blood pressure when starting or adjusting either drug. Reduce the diuretic dose or review hydration if hypotension appears.
What other medicines interact with Carbidopa-levodopa?
MediHelp also lists interactions of Carbidopa-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-levodopa page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
