Drug interactions
Carbidopa-levodopa + Furosemide
Severity: Moderate
Carbidopa-levodopa and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can lower blood pressure, particularly on standing, and furosemide adds to this through volume depletion. Patients may experience dizziness, falls or syncope, especially early in treatment or after dose increases.
What this interaction means in plain words
Carbidopa-levodopa and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-levodopa belongs to Central Nervous System; Furosemide belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotension: levodopa-derived dopamine causes vasodilation and autonomic effects, while furosemide reduces circulating volume.
What to do
Monitor supine and standing blood pressure when starting or adjusting either drug. Reduce the diuretic dose if symptomatic orthostatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-levodopa
- Carbidopa-levodopa + Isocarboxazid Contraindicated
- Carbidopa-levodopa + Phenelzine Contraindicated
- Carbidopa-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-levodopa Major
- Asenapine + Carbidopa-levodopa Major
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Carbidopa-levodopa with Furosemide?
MediHelp rates the interaction as moderate. Carbidopa-levodopa and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can lower blood pressure, particularly on standing, and furosemide adds to this through volume depletion. Patients may experience dizziness, falls or syncope, especially early in treatment or after dose increases.
How serious is the interaction between Carbidopa-levodopa and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure when starting or adjusting either drug. Reduce the diuretic dose if symptomatic orthostatic hypotension develops.
What other medicines interact with Carbidopa-levodopa?
MediHelp also lists interactions of Carbidopa-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-levodopa page.
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