Drug interactions
Carbidopa-levodopa + Levomilnacipran
Severity: Minor
Carbidopa-levodopa and Levomilnacipran: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levomilnacipran is a serotonin-norepinephrine reuptake inhibitor, and levodopa is not a classic serotonergic drug. Levodopa may modestly affect monoamine levels, but serotonin syndrome risk is not well established; blood pressure effects are also possible.
What this interaction means in plain words
Carbidopa-levodopa and Levomilnacipran have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbidopa-levodopa belongs to Central Nervous System; Levomilnacipran belongs to Central Nervous System.
Why it happens
Possible additive monoaminergic effects; mechanism not firmly established.
What to do
Monitor for blood pressure changes, agitation and signs of serotonin toxicity when starting or adjusting either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carbidopa-levodopa
- Carbidopa-levodopa + Isocarboxazid Contraindicated
- Carbidopa-levodopa + Phenelzine Contraindicated
- Carbidopa-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-levodopa Major
- Asenapine + Carbidopa-levodopa Major
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Carbidopa-levodopa with Levomilnacipran?
MediHelp rates the interaction as minor. Carbidopa-levodopa and Levomilnacipran have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levomilnacipran is a serotonin-norepinephrine reuptake inhibitor, and levodopa is not a classic serotonergic drug. Levodopa may modestly affect monoamine levels, but serotonin syndrome risk is not well established; blood pressure effects are also possible.
How serious is the interaction between Carbidopa-levodopa and Levomilnacipran?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for blood pressure changes, agitation and signs of serotonin toxicity when starting or adjusting either drug.
What other medicines interact with Carbidopa-levodopa?
MediHelp also lists interactions of Carbidopa-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-levodopa page.
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