Drug interactions
Carbinoxamine + Chlorpheniramine
Severity: Moderate
Carbinoxamine and Chlorpheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are first-generation sedating antihistamines, so combining them duplicates therapy and adds to sedation and anticholinergic effects such as dry mouth, urinary retention and confusion. Older adults are particularly vulnerable.
What this interaction means in plain words
Carbinoxamine and Chlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbinoxamine belongs to Respiratory; Chlorpheniramine belongs to Respiratory.
Why it happens
Additive H1-receptor blockade with antimuscarinic and central sedative effects.
What to do
Avoid using two first-generation antihistamines together; keep only one agent. Monitor for excessive sedation and anticholinergic effects if both cannot be avoided.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpheniramine
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Carbinoxamine with Chlorpheniramine?
MediHelp rates the interaction as moderate. Carbinoxamine and Chlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are first-generation sedating antihistamines, so combining them duplicates therapy and adds to sedation and anticholinergic effects such as dry mouth, urinary retention and confusion. Older adults are particularly vulnerable.
How serious is the interaction between Carbinoxamine and Chlorpheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two first-generation antihistamines together; keep only one agent. Monitor for excessive sedation and anticholinergic effects if both cannot be avoided.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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