Drug interactions
Carbinoxamine + Chlorzoxazone
Severity: Moderate
Carbinoxamine and Chlorzoxazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbinoxamine is a sedating first-generation antihistamine and chlorzoxazone also causes drowsiness. Used together they can produce excessive sedation and reduced alertness.
What this interaction means in plain words
Carbinoxamine and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbinoxamine belongs to Respiratory; Chlorzoxazone belongs to Musculoskeletal.
Why it happens
Additive CNS depression from central H1-receptor antagonism and the central muscle relaxant effect of chlorzoxazone.
What to do
Advise patients to avoid driving and hazardous tasks until their response is known. Consider a non-sedating antihistamine if the combination is not tolerated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Carbinoxamine with Chlorzoxazone?
MediHelp rates the interaction as moderate. Carbinoxamine and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbinoxamine is a sedating first-generation antihistamine and chlorzoxazone also causes drowsiness. Used together they can produce excessive sedation and reduced alertness.
How serious is the interaction between Carbinoxamine and Chlorzoxazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving and hazardous tasks until their response is known. Consider a non-sedating antihistamine if the combination is not tolerated.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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