Drug interactions
Carbinoxamine + Cyclizine
Severity: Moderate
Carbinoxamine and Cyclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are sedating first-generation antihistamines with anticholinergic effects. Using them together duplicates therapy and increases drowsiness, dry mouth, confusion and urinary retention.
What this interaction means in plain words
Carbinoxamine and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbinoxamine belongs to Respiratory; Cyclizine belongs to Respiratory.
Why it happens
Additive H1 antihistaminic, antimuscarinic and CNS depressant effects.
What to do
Avoid concurrent use of two sedating antihistamines where possible and counsel against driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Carbinoxamine with Cyclizine?
MediHelp rates the interaction as moderate. Carbinoxamine and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are sedating first-generation antihistamines with anticholinergic effects. Using them together duplicates therapy and increases drowsiness, dry mouth, confusion and urinary retention.
How serious is the interaction between Carbinoxamine and Cyclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two sedating antihistamines where possible and counsel against driving.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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