Drug interactions
Carbinoxamine + Maprotiline
Severity: Moderate
Carbinoxamine and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating and have antihistaminic and anticholinergic activity, so taking them together can intensify drowsiness, impair psychomotor performance and increase anticholinergic effects such as dry mouth, urinary retention and constipation. Elderly patients are particularly vulnerable.
What this interaction means in plain words
Carbinoxamine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbinoxamine belongs to Respiratory; Maprotiline belongs to Central Nervous System.
Why it happens
Additive CNS depression and anticholinergic effects from H1-receptor and muscarinic blockade.
What to do
Warn the patient about drowsiness and avoid driving or operating machinery until the response is known. Consider a non-sedating antihistamine if an antihistamine is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Carbinoxamine with Maprotiline?
MediHelp rates the interaction as moderate. Carbinoxamine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating and have antihistaminic and anticholinergic activity, so taking them together can intensify drowsiness, impair psychomotor performance and increase anticholinergic effects such as dry mouth, urinary retention and constipation. Elderly patients are particularly vulnerable.
How serious is the interaction between Carbinoxamine and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient about drowsiness and avoid driving or operating machinery until the response is known. Consider a non-sedating antihistamine if an antihistamine is needed.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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