Drug interactions
Carbinoxamine + Tranylcypromine
Severity: Moderate
Carbinoxamine and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can prolong and intensify the anticholinergic effects of antihistamines such as carbinoxamine, and the two also add to CNS depression. This may cause marked sedation, dry mouth, urinary retention, confusion and tachycardia.
What this interaction means in plain words
Carbinoxamine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbinoxamine belongs to Respiratory; Tranylcypromine belongs to Central Nervous System.
Why it happens
MAO inhibition combined with antihistamine anticholinergic and sedative effects produces additive pharmacodynamic toxicity.
What to do
Prefer a non-sedating second-generation antihistamine or a non-drug alternative. If carbinoxamine is used, give the lowest dose and monitor for sedation and anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Carbinoxamine and Tranylcypromine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Carbinoxamine with Tranylcypromine?
MediHelp rates the interaction as moderate. Carbinoxamine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors can prolong and intensify the anticholinergic effects of antihistamines such as carbinoxamine, and the two also add to CNS depression. This may cause marked sedation, dry mouth, urinary retention, confusion and tachycardia.
How serious is the interaction between Carbinoxamine and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-sedating second-generation antihistamine or a non-drug alternative. If carbinoxamine is used, give the lowest dose and monitor for sedation and anticholinergic effects.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
