Drug interactions
Carbinoxamine + Ziprasidone
Severity: Moderate
Carbinoxamine and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbinoxamine is a sedating first-generation antihistamine with anticholinergic effects. With ziprasidone it may cause additive drowsiness, dizziness and impaired alertness.
What this interaction means in plain words
Carbinoxamine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbinoxamine belongs to Respiratory; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive CNS depression through H1-receptor antagonism and antipsychotic sedative effects.
What to do
Warn patients about sedation and avoid driving or alcohol. Consider a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Carbinoxamine with Ziprasidone?
MediHelp rates the interaction as moderate. Carbinoxamine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbinoxamine is a sedating first-generation antihistamine with anticholinergic effects. With ziprasidone it may cause additive drowsiness, dizziness and impaired alertness.
How serious is the interaction between Carbinoxamine and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about sedation and avoid driving or alcohol. Consider a non-sedating antihistamine.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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