Drug interactions
Carboplatin + Paromomycin
Severity: Minor
Carboplatin and Paromomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral paromomycin is minimally absorbed, but absorption may rise with intestinal ulceration or renal impairment. In that setting it could add to carboplatin renal toxicity and ototoxicity, though the risk is low.
What this interaction means in plain words
Carboplatin and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carboplatin belongs to Oncology; Paromomycin belongs to Anti Bacterial.
Why it happens
Possible additive nephrotoxicity and ototoxicity if systemic aminoglycoside absorption occurs.
What to do
Monitor renal function during combined use, particularly with mucositis or reduced kidney function. No dose change is needed in most patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carboplatin
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Carboplatin with Paromomycin?
MediHelp rates the interaction as minor. Carboplatin and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral paromomycin is minimally absorbed, but absorption may rise with intestinal ulceration or renal impairment. In that setting it could add to carboplatin renal toxicity and ototoxicity, though the risk is low.
How serious is the interaction between Carboplatin and Paromomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function during combined use, particularly with mucositis or reduced kidney function. No dose change is needed in most patients.
What other medicines interact with Carboplatin?
MediHelp also lists interactions of Carboplatin with, for example, Adenovirus types 4 and 7 live, Amikacin, Amphotericin b deoxycholate. The full list is on the Carboplatin page.
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