Drug interactions
Carfilzomib + Erdafitinib
Severity: Minor
Carfilzomib and Erdafitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib inhibits P-glycoprotein, and carfilzomib is a P-gp substrate. Carfilzomib is cleared mainly by peptidases rather than P-gp, so the clinical effect is probably small.
What this interaction means in plain words
Carfilzomib and Erdafitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carfilzomib belongs to Oncology; Erdafitinib belongs to Oncology.
Why it happens
Erdafitinib inhibits P-gp, which may slightly raise carfilzomib exposure.
What to do
No routine adjustment is needed. Monitor for carfilzomib toxicity such as cardiac and renal effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carfilzomib
- Carfilzomib + Etrasimod Major
- Carfilzomib + Ropeginterferon alfa 2b Major
- Carfilzomib + Dichlorphenamide Moderate
- Carfilzomib + Palifermin Moderate
- Carfilzomib + Ponesimod Moderate
- Carfilzomib + Siponimod Moderate
Other interactions of Erdafitinib
Frequently asked questions
Can I take Carfilzomib with Erdafitinib?
MediHelp rates the interaction as minor. Carfilzomib and Erdafitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erdafitinib inhibits P-glycoprotein, and carfilzomib is a P-gp substrate. Carfilzomib is cleared mainly by peptidases rather than P-gp, so the clinical effect is probably small.
How serious is the interaction between Carfilzomib and Erdafitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for carfilzomib toxicity such as cardiac and renal effects.
What other medicines interact with Carfilzomib?
MediHelp also lists interactions of Carfilzomib with, for example, Etrasimod, Ropeginterferon alfa 2b, Dichlorphenamide. The full list is on the Carfilzomib page.
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