Drug interactions
Carfilzomib + Sotorasib
Severity: Minor
Carfilzomib and Sotorasib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib can induce P-gp and could lower exposure to P-gp substrates. Carfilzomib is cleared mainly by peptidases, so any effect is likely small.
What this interaction means in plain words
Carfilzomib and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carfilzomib belongs to Oncology; Sotorasib belongs to Oncology.
Why it happens
Sotorasib may induce P-gp, increasing efflux of carfilzomib.
What to do
No adjustment needed; monitor for response as routine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carfilzomib
- Carfilzomib + Etrasimod Major
- Carfilzomib + Ropeginterferon alfa 2b Major
- Carfilzomib + Dichlorphenamide Moderate
- Carfilzomib + Palifermin Moderate
- Carfilzomib + Ponesimod Moderate
- Carfilzomib + Siponimod Moderate
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Carfilzomib with Sotorasib?
MediHelp rates the interaction as minor. Carfilzomib and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sotorasib can induce P-gp and could lower exposure to P-gp substrates. Carfilzomib is cleared mainly by peptidases, so any effect is likely small.
How serious is the interaction between Carfilzomib and Sotorasib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment needed; monitor for response as routine.
What other medicines interact with Carfilzomib?
MediHelp also lists interactions of Carfilzomib with, for example, Etrasimod, Ropeginterferon alfa 2b, Dichlorphenamide. The full list is on the Carfilzomib page.
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