Drug interactions
Cariprazine + Chloramphenicol
Severity: Moderate
Cariprazine and Chloramphenicol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may raise cariprazine and its active metabolite levels by inhibiting CYP3A4. Because these have long half-lives, increased exposure may cause prolonged adverse effects such as akathisia and sedation.
What this interaction means in plain words
Cariprazine and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Chloramphenicol belongs to Anti Bacterial.
Why it happens
Chloramphenicol inhibits CYP3A4, which is the main route of cariprazine metabolism.
What to do
Monitor for extrapyramidal symptoms, akathisia and sedation for several weeks, and reduce the cariprazine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Chloramphenicol?
MediHelp rates the interaction as moderate. Cariprazine and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol may raise cariprazine and its active metabolite levels by inhibiting CYP3A4. Because these have long half-lives, increased exposure may cause prolonged adverse effects such as akathisia and sedation.
How serious is the interaction between Cariprazine and Chloramphenicol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, akathisia and sedation for several weeks, and reduce the cariprazine dose if needed.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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