Drug interactions
Cariprazine + Chlorzoxazone
Severity: Moderate
Cariprazine and Chlorzoxazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorzoxazone and cariprazine can both cause somnolence and dizziness. Used together, impaired alertness and psychomotor function may be more pronounced.
What this interaction means in plain words
Cariprazine and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Chlorzoxazone belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for excess sedation and dizziness, especially when starting or increasing either drug. Counsel the patient on driving and machinery use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Chlorzoxazone?
MediHelp rates the interaction as moderate. Cariprazine and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorzoxazone and cariprazine can both cause somnolence and dizziness. Used together, impaired alertness and psychomotor function may be more pronounced.
How serious is the interaction between Cariprazine and Chlorzoxazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and dizziness, especially when starting or increasing either drug. Counsel the patient on driving and machinery use.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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