Drug interactions
Cariprazine + Desipramine
Severity: Moderate
Cariprazine and Desipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause sedation, dizziness and orthostatic effects, which may be additive. Cariprazine is mainly metabolised by CYP3A4 and desipramine has no major effect on that pathway.
What this interaction means in plain words
Cariprazine and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Desipramine belongs to Central Nervous System.
Why it happens
Additive CNS depressant and hypotensive effects.
What to do
Monitor for sedation, orthostatic hypotension and akathisia, and adjust doses as needed; counsel on driving and fall risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Desipramine?
MediHelp rates the interaction as moderate. Cariprazine and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause sedation, dizziness and orthostatic effects, which may be additive. Cariprazine is mainly metabolised by CYP3A4 and desipramine has no major effect on that pathway.
How serious is the interaction between Cariprazine and Desipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostatic hypotension and akathisia, and adjust doses as needed; counsel on driving and fall risk.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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