Drug interactions
Cariprazine + Deutetrabenazine
Severity: Major
Cariprazine and Deutetrabenazine: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs affect dopaminergic transmission, so combined use may increase parkinsonism, akathisia, sedation and the risk of neuroleptic malignant syndrome. Deutetrabenazine also carries depression and QT concerns.
What this interaction means in plain words
Cariprazine and Deutetrabenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cariprazine belongs to Central Nervous System; Deutetrabenazine belongs to Central Nervous System.
Why it happens
Additive dopamine antagonism (D2/D3 partial agonism) and VMAT2 inhibition-mediated dopamine depletion, with additive sedation.
What to do
Monitor closely for movement disorders, fever or rigidity, sedation and mood changes. Reduce doses or stop one agent if extrapyramidal or neuroleptic malignant symptoms appear.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cariprazine
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Cariprazine with Deutetrabenazine?
MediHelp rates the interaction as major. Cariprazine and Deutetrabenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs affect dopaminergic transmission, so combined use may increase parkinsonism, akathisia, sedation and the risk of neuroleptic malignant syndrome. Deutetrabenazine also carries depression and QT concerns.
How serious is the interaction between Cariprazine and Deutetrabenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for movement disorders, fever or rigidity, sedation and mood changes. Reduce doses or stop one agent if extrapyramidal or neuroleptic malignant symptoms appear.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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