Drug interactions
Cariprazine + Guanfacine
Severity: Moderate
Cariprazine and Guanfacine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Guanfacine commonly causes somnolence, hypotension and bradycardia, and cariprazine may also cause sedation and orthostasis. Using both can increase drowsiness and the risk of dizziness or falls.
What this interaction means in plain words
Cariprazine and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Guanfacine belongs to Cardiovascular.
Why it happens
Additive sedation and hypotensive effects (pharmacodynamic).
What to do
Monitor sedation, blood pressure and heart rate, and rise slowly from sitting. Adjust guanfacine dose if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Guanfacine
- Clonidine + Guanfacine Major
- Guanfacine + Lofexidine Major
- Aldesleukin + Guanfacine Moderate
- Amiodarone + Guanfacine Moderate
- Amisulpride + Guanfacine Moderate
- Amitriptyline + Guanfacine Moderate
Frequently asked questions
Can I take Cariprazine with Guanfacine?
MediHelp rates the interaction as moderate. Cariprazine and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Guanfacine commonly causes somnolence, hypotension and bradycardia, and cariprazine may also cause sedation and orthostasis. Using both can increase drowsiness and the risk of dizziness or falls.
How serious is the interaction between Cariprazine and Guanfacine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and heart rate, and rise slowly from sitting. Adjust guanfacine dose if symptomatic.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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