Drug interactions
Cariprazine + Hydrocodone
Severity: Moderate
Cariprazine and Hydrocodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining hydrocodone with cariprazine can add to sedation, dizziness and cognitive or psychomotor impairment. Respiratory depression is less typical than with sedative-hypnotics but can occur in vulnerable patients.
What this interaction means in plain words
Cariprazine and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Hydrocodone belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression from opioid agonism and the sedating effects of the antipsychotic.
What to do
Use the lowest effective hydrocodone dose for the shortest duration and monitor for excessive sedation and respiratory depression, especially at initiation and after dose increases. Counsel the patient about driving and operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Hydrocodone?
MediHelp rates the interaction as moderate. Cariprazine and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining hydrocodone with cariprazine can add to sedation, dizziness and cognitive or psychomotor impairment. Respiratory depression is less typical than with sedative-hypnotics but can occur in vulnerable patients.
How serious is the interaction between Cariprazine and Hydrocodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective hydrocodone dose for the shortest duration and monitor for excessive sedation and respiratory depression, especially at initiation and after dose increases. Counsel the patient about driving and operating machinery.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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