Drug interactions
Cariprazine + Imatinib
Severity: Moderate
Cariprazine and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP3A4 and may raise cariprazine and its active metabolites, which have long half-lives. Greater exposure may increase akathisia, extrapyramidal symptoms, and sedation.
What this interaction means in plain words
Cariprazine and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Imatinib belongs to Oncology.
Why it happens
Imatinib inhibits CYP3A4, reducing cariprazine metabolism.
What to do
Monitor for extrapyramidal symptoms, akathisia, and sedation, and consider lowering the cariprazine dose. Allow for slow changes because of the long half-life of the active metabolites.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Cariprazine with Imatinib?
MediHelp rates the interaction as moderate. Cariprazine and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib inhibits CYP3A4 and may raise cariprazine and its active metabolites, which have long half-lives. Greater exposure may increase akathisia, extrapyramidal symptoms, and sedation.
How serious is the interaction between Cariprazine and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, akathisia, and sedation, and consider lowering the cariprazine dose. Allow for slow changes because of the long half-life of the active metabolites.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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