Drug interactions
Cariprazine + Lenacapavir
Severity: Moderate
Cariprazine and Lenacapavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A4 inhibitor, and the effect can persist for months after subcutaneous dosing. Cariprazine is cleared by CYP3A4, so its exposure may increase and cause more adverse effects.
What this interaction means in plain words
Cariprazine and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Lenacapavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4-mediated cariprazine metabolism by lenacapavir.
What to do
Monitor for akathisia, sedation and extrapyramidal effects and consider lowering the cariprazine dose. Continue monitoring for months after the last lenacapavir injection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Cariprazine with Lenacapavir?
MediHelp rates the interaction as moderate. Cariprazine and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A4 inhibitor, and the effect can persist for months after subcutaneous dosing. Cariprazine is cleared by CYP3A4, so its exposure may increase and cause more adverse effects.
How serious is the interaction between Cariprazine and Lenacapavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for akathisia, sedation and extrapyramidal effects and consider lowering the cariprazine dose. Continue monitoring for months after the last lenacapavir injection.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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