Drug interactions
Cariprazine + Linezolid
Severity: Moderate
Cariprazine and Linezolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid, a weak MAO inhibitor, may add to the serotonergic activity of cariprazine and could precipitate serotonin syndrome. The risk is theoretical, based on class effects, with few clinical reports.
What this interaction means in plain words
Cariprazine and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Linezolid belongs to Anti Bacterial.
Why it happens
Additive serotonergic effect from MAO inhibition by linezolid and cariprazine's serotonin receptor activity.
What to do
Monitor for signs of serotonin toxicity and neuroleptic malignant syndrome during the linezolid course. Withdraw the interacting drugs and treat supportively if features develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cariprazine and Linezolid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Linezolid?
MediHelp rates the interaction as moderate. Cariprazine and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linezolid, a weak MAO inhibitor, may add to the serotonergic activity of cariprazine and could precipitate serotonin syndrome. The risk is theoretical, based on class effects, with few clinical reports.
How serious is the interaction between Cariprazine and Linezolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity and neuroleptic malignant syndrome during the linezolid course. Withdraw the interacting drugs and treat supportively if features develop.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
