Drug interactions
Cariprazine + Mifepristone
Severity: Major
Cariprazine and Mifepristone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone, particularly at the higher doses used for Cushing syndrome, inhibits CYP3A4 and can raise cariprazine and active metabolite exposure. Higher exposure increases the risk of adverse effects such as akathisia, parkinsonism, sedation and metabolic effects.
What this interaction means in plain words
Cariprazine and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cariprazine belongs to Central Nervous System; Mifepristone belongs to Endocrine.
Why it happens
Mifepristone inhibits CYP3A4, reducing the clearance of cariprazine and its active metabolites.
What to do
Where possible choose an alternative, or reduce the cariprazine dose as advised in labeling for strong CYP3A4 inhibitors. Monitor for extrapyramidal and sedative adverse effects for several weeks because of the long half-life of cariprazine's metabolites.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cariprazine
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Cariprazine with Mifepristone?
MediHelp rates the interaction as major. Cariprazine and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone, particularly at the higher doses used for Cushing syndrome, inhibits CYP3A4 and can raise cariprazine and active metabolite exposure. Higher exposure increases the risk of adverse effects such as akathisia, parkinsonism, sedation and metabolic effects.
How serious is the interaction between Cariprazine and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible choose an alternative, or reduce the cariprazine dose as advised in labeling for strong CYP3A4 inhibitors. Monitor for extrapyramidal and sedative adverse effects for several weeks because of the long half-life of cariprazine's metabolites.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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