Drug interactions
Cariprazine + Naratriptan
Severity: Moderate
Cariprazine and Naratriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents affect serotonin signaling, so serotonin toxicity is a theoretical concern with combined use. Antipsychotics also carry a risk of neuroleptic malignant syndrome. Case reports for this pair are lacking and the actual risk appears low.
What this interaction means in plain words
Cariprazine and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Naratriptan belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects from 5-HT1B/1D agonism and cariprazine's 5-HT1A partial agonism; not firmly established.
What to do
Advise the patient to report agitation, tremor, sweating, fever or rigidity. Monitor mental status and autonomic function after starting or changing doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Cariprazine with Naratriptan?
MediHelp rates the interaction as moderate. Cariprazine and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents affect serotonin signaling, so serotonin toxicity is a theoretical concern with combined use. Antipsychotics also carry a risk of neuroleptic malignant syndrome. Case reports for this pair are lacking and the actual risk appears low.
How serious is the interaction between Cariprazine and Naratriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise the patient to report agitation, tremor, sweating, fever or rigidity. Monitor mental status and autonomic function after starting or changing doses.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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