Drug interactions
Cariprazine + Oxymorphone
Severity: Moderate
Cariprazine and Oxymorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cariprazine may add to the sedation, dizziness and orthostatic hypotension caused by oxymorphone. The combination can impair alertness and, at higher doses, raise respiratory depression risk.
What this interaction means in plain words
Cariprazine and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Oxymorphone belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression and hypotensive effects.
What to do
Use the lowest effective doses and titrate gradually. Monitor sedation, blood pressure and respiratory status.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Oxymorphone?
MediHelp rates the interaction as moderate. Cariprazine and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cariprazine may add to the sedation, dizziness and orthostatic hypotension caused by oxymorphone. The combination can impair alertness and, at higher doses, raise respiratory depression risk.
How serious is the interaction between Cariprazine and Oxymorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and titrate gradually. Monitor sedation, blood pressure and respiratory status.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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