Drug interactions
Cariprazine + Procarbazine
Severity: Moderate
Cariprazine and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has weak monoamine oxidase inhibitory activity and can potentiate serotonergic and CNS-depressant drugs, while cariprazine affects dopamine and serotonin receptors. The combination could theoretically increase the risk of serotonin toxicity, sedation or neuroleptic malignant syndrome. Direct evidence for this pair is limited.
What this interaction means in plain words
Cariprazine and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
Possible additive serotonergic and CNS-depressant effects because of procarbazine's MAO-inhibiting properties; not firmly established.
What to do
Monitor for agitation, hyperthermia, rigidity, tremor and autonomic instability, and for excessive sedation. Seek oncology and psychiatry input if the antipsychotic is considered necessary during procarbazine therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Cariprazine with Procarbazine?
MediHelp rates the interaction as moderate. Cariprazine and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine has weak monoamine oxidase inhibitory activity and can potentiate serotonergic and CNS-depressant drugs, while cariprazine affects dopamine and serotonin receptors. The combination could theoretically increase the risk of serotonin toxicity, sedation or neuroleptic malignant syndrome. Direct evidence for this pair is limited.
How serious is the interaction between Cariprazine and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, hyperthermia, rigidity, tremor and autonomic instability, and for excessive sedation. Seek oncology and psychiatry input if the antipsychotic is considered necessary during procarbazine therapy.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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