Drug interactions
Cariprazine + Secobarbital
Severity: Moderate
Cariprazine and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may reduce exposure to cariprazine and its active metabolites, possibly weakening antipsychotic control. Sedation may also be additive.
What this interaction means in plain words
Cariprazine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturate induction of CYP3A4 increases clearance of cariprazine and its active metabolites.
What to do
Monitor for loss of symptom control and adjust the cariprazine dose as needed; reassess if the barbiturate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Secobarbital?
MediHelp rates the interaction as moderate. Cariprazine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital may reduce exposure to cariprazine and its active metabolites, possibly weakening antipsychotic control. Sedation may also be additive.
How serious is the interaction between Cariprazine and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of symptom control and adjust the cariprazine dose as needed; reassess if the barbiturate is stopped.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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