Drug interactions
Cariprazine + Tetrabenazine
Severity: Moderate
Cariprazine and Tetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents act on dopamine pathways and cause somnolence, so combined use may increase sedation and impair alertness. Additive extrapyramidal effects, parkinsonism, akathisia and depression are also possible.
What this interaction means in plain words
Cariprazine and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Tetrabenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and dopaminergic antagonism or depletion (D2 blockade by cariprazine, VMAT2 inhibition by tetrabenazine).
What to do
Monitor for sedation, extrapyramidal symptoms and mood changes, and reduce the dose of one agent if these occur. Avoid combining if possible in patients with a history of depression or suicidality.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Tetrabenazine
- Dronedarone + Tetrabenazine Contraindicated
- Isocarboxazid + Tetrabenazine Contraindicated
- Linezolid + Tetrabenazine Contraindicated
- Phenelzine + Tetrabenazine Contraindicated
- Pimozide + Tetrabenazine Contraindicated
- Procarbazine + Tetrabenazine Contraindicated
Frequently asked questions
Can I take Cariprazine with Tetrabenazine?
MediHelp rates the interaction as moderate. Cariprazine and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents act on dopamine pathways and cause somnolence, so combined use may increase sedation and impair alertness. Additive extrapyramidal effects, parkinsonism, akathisia and depression are also possible.
How serious is the interaction between Cariprazine and Tetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, extrapyramidal symptoms and mood changes, and reduce the dose of one agent if these occur. Avoid combining if possible in patients with a history of depression or suicidality.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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