Drug interactions
Cariprazine + Tolcapone
Severity: Moderate
Cariprazine and Tolcapone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolcapone increases dopaminergic activity and may oppose the dopamine antagonism of cariprazine, while both can cause somnolence and dizziness. Psychiatric symptoms such as hallucinations may worsen and Parkinson symptoms may not be controlled.
What this interaction means in plain words
Cariprazine and Tolcapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Tolcapone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between D2 blockade and enhanced dopaminergic tone, plus additive CNS effects.
What to do
Monitor motor function, psychiatric symptoms and sedation. Adjust doses based on response, and consider a different antipsychotic in Parkinson disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Tolcapone
- Isocarboxazid + Tolcapone Contraindicated
- Phenelzine + Tolcapone Contraindicated
- Tolcapone + Tranylcypromine Contraindicated
- Metoclopramide + Tolcapone Major
- Apomorphine + Tolcapone Moderate
- Asenapine + Tolcapone Moderate
Frequently asked questions
Can I take Cariprazine with Tolcapone?
MediHelp rates the interaction as moderate. Cariprazine and Tolcapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolcapone increases dopaminergic activity and may oppose the dopamine antagonism of cariprazine, while both can cause somnolence and dizziness. Psychiatric symptoms such as hallucinations may worsen and Parkinson symptoms may not be controlled.
How serious is the interaction between Cariprazine and Tolcapone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor function, psychiatric symptoms and sedation. Adjust doses based on response, and consider a different antipsychotic in Parkinson disease.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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