Drug interactions
Cariprazine + Tranylcypromine
Severity: Moderate
Cariprazine and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cariprazine is a dopamine and serotonin receptor partial agonist and may add to monoamine effects of an MAO inhibitor. This raises the possibility of serotonin toxicity, NMS or blood pressure changes.
What this interaction means in plain words
Cariprazine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
MAO inhibition combined with dopamine D2/D3 and serotonin receptor activity.
What to do
Monitor for signs of serotonin toxicity and NMS, particularly after dose changes. Stop therapy and treat promptly if symptoms emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Tranylcypromine?
MediHelp rates the interaction as moderate. Cariprazine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cariprazine is a dopamine and serotonin receptor partial agonist and may add to monoamine effects of an MAO inhibitor. This raises the possibility of serotonin toxicity, NMS or blood pressure changes.
How serious is the interaction between Cariprazine and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity and NMS, particularly after dose changes. Stop therapy and treat promptly if symptoms emerge.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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