Drug interactions
Cariprazine + Valproic acid
Severity: Minor
Cariprazine and Valproic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valproate and cariprazine are often used together in bipolar disorder. Both can cause sedation and dizziness, and the combination may be additive. No clinically significant pharmacokinetic interaction is expected.
What this interaction means in plain words
Cariprazine and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cariprazine belongs to Central Nervous System; Valproic acid belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for excessive sedation and dizziness, particularly during initiation and dose changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cariprazine
Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Frequently asked questions
Can I take Cariprazine with Valproic acid?
MediHelp rates the interaction as minor. Cariprazine and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valproate and cariprazine are often used together in bipolar disorder. Both can cause sedation and dizziness, and the combination may be additive. No clinically significant pharmacokinetic interaction is expected.
How serious is the interaction between Cariprazine and Valproic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and dizziness, particularly during initiation and dose changes.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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