Drug interactions
Cariprazine + Voxelotor
Severity: Moderate
Cariprazine and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor can inhibit CYP3A4 and increase exposure to sensitive substrates such as cariprazine. This may increase dose-related adverse effects including akathisia, parkinsonism and sedation.
What this interaction means in plain words
Cariprazine and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Voxelotor belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4-mediated metabolism of cariprazine.
What to do
Monitor for adverse effects and consider lowering the cariprazine dose if symptoms appear. Reassess dosing after voxelotor is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Cariprazine with Voxelotor?
MediHelp rates the interaction as moderate. Cariprazine and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor can inhibit CYP3A4 and increase exposure to sensitive substrates such as cariprazine. This may increase dose-related adverse effects including akathisia, parkinsonism and sedation.
How serious is the interaction between Cariprazine and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects and consider lowering the cariprazine dose if symptoms appear. Reassess dosing after voxelotor is stopped.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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