Drug interactions
Cariprazine + Ziprasidone
Severity: Moderate
Cariprazine and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using two antipsychotics together increases sedation, extrapyramidal effects and orthostatic hypotension. Ziprasidone also prolongs the QT interval, which makes the combination less desirable.
What this interaction means in plain words
Cariprazine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive dopamine and serotonin receptor effects and CNS depression, with QT prolongation from ziprasidone.
What to do
Avoid combining where possible. If both are used, obtain a baseline ECG, check potassium and magnesium, and monitor for movement disorders and sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Cariprazine with Ziprasidone?
MediHelp rates the interaction as moderate. Cariprazine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using two antipsychotics together increases sedation, extrapyramidal effects and orthostatic hypotension. Ziprasidone also prolongs the QT interval, which makes the combination less desirable.
How serious is the interaction between Cariprazine and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible. If both are used, obtain a baseline ECG, check potassium and magnesium, and monitor for movement disorders and sedation.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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