Drug interactions
Carisoprodol + Fedratinib
Severity: Moderate
Carisoprodol and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP2C19, the main enzyme converting carisoprodol to meprobamate, so carisoprodol exposure may rise. This may increase sedation and other adverse effects of carisoprodol.
What this interaction means in plain words
Carisoprodol and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carisoprodol belongs to Musculoskeletal; Fedratinib belongs to Oncology.
Why it happens
Inhibition of CYP2C19-mediated metabolism of carisoprodol by fedratinib.
What to do
Monitor for increased drowsiness and dizziness and consider a lower carisoprodol dose during fedratinib therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carisoprodol
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Carisoprodol with Fedratinib?
MediHelp rates the interaction as moderate. Carisoprodol and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP2C19, the main enzyme converting carisoprodol to meprobamate, so carisoprodol exposure may rise. This may increase sedation and other adverse effects of carisoprodol.
How serious is the interaction between Carisoprodol and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased drowsiness and dizziness and consider a lower carisoprodol dose during fedratinib therapy.
What other medicines interact with Carisoprodol?
MediHelp also lists interactions of Carisoprodol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Carisoprodol page.
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