Drug interactions
Carisoprodol + Oxycodone
Severity: Major
Carisoprodol and Oxycodone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, and combined use increases the risk of profound sedation, respiratory depression, coma and death. Carisoprodol is also metabolized to meprobamate, a sedative, and the combination is a recognized misuse pattern.
What this interaction means in plain words
Carisoprodol and Oxycodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carisoprodol belongs to Musculoskeletal; Oxycodone belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression.
What to do
Avoid the combination where possible; if it is necessary, use the lowest effective doses for the shortest duration and monitor for sedation and respiratory depression. Counsel patients to avoid alcohol and driving.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Carisoprodol
Frequently asked questions
Can I take Carisoprodol with Oxycodone?
MediHelp rates the interaction as major. Carisoprodol and Oxycodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs depress the central nervous system, and combined use increases the risk of profound sedation, respiratory depression, coma and death. Carisoprodol is also metabolized to meprobamate, a sedative, and the combination is a recognized misuse pattern.
How serious is the interaction between Carisoprodol and Oxycodone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if it is necessary, use the lowest effective doses for the shortest duration and monitor for sedation and respiratory depression. Counsel patients to avoid alcohol and driving.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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