Drug interactions
Carisoprodol + Stiripentol
Severity: Moderate
Carisoprodol and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits CYP2C19, which raises carisoprodol levels and may reduce meprobamate formation. Stiripentol also causes somnolence, so sedation may be additive.
What this interaction means in plain words
Carisoprodol and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carisoprodol belongs to Musculoskeletal; Stiripentol belongs to Central Nervous System.
Why it happens
CYP2C19 inhibition by stiripentol, plus additive CNS depression.
What to do
Monitor for excessive sedation and consider lowering the carisoprodol dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carisoprodol
Other interactions of Stiripentol
Frequently asked questions
Can I take Carisoprodol with Stiripentol?
MediHelp rates the interaction as moderate. Carisoprodol and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits CYP2C19, which raises carisoprodol levels and may reduce meprobamate formation. Stiripentol also causes somnolence, so sedation may be additive.
How serious is the interaction between Carisoprodol and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and consider lowering the carisoprodol dose.
What other medicines interact with Carisoprodol?
MediHelp also lists interactions of Carisoprodol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Carisoprodol page.
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