Drug interactions
Carisoprodol + Trazodone
Severity: Moderate
Carisoprodol and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone is a sedating antidepressant and carisoprodol is a centrally acting muscle relaxant. Combined use may cause additive drowsiness, dizziness and orthostatic hypotension, which can impair driving and raise fall risk.
What this interaction means in plain words
Carisoprodol and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carisoprodol belongs to Musculoskeletal; Trazodone belongs to Central Nervous System.
Why it happens
Additive CNS depression, with trazodone's antihistaminic and alpha-1 blocking actions contributing to sedation and hypotension.
What to do
Start with low doses and counsel the patient about driving and alcohol. Reduce the dose of one drug if sedation or dizziness is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carisoprodol
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Carisoprodol with Trazodone?
MediHelp rates the interaction as moderate. Carisoprodol and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone is a sedating antidepressant and carisoprodol is a centrally acting muscle relaxant. Combined use may cause additive drowsiness, dizziness and orthostatic hypotension, which can impair driving and raise fall risk.
How serious is the interaction between Carisoprodol and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and counsel the patient about driving and alcohol. Reduce the dose of one drug if sedation or dizziness is troublesome.
What other medicines interact with Carisoprodol?
MediHelp also lists interactions of Carisoprodol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Carisoprodol page.
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