Drug interactions
Carisoprodol + Triclabendazole
Severity: Moderate
Carisoprodol and Triclabendazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carisoprodol is metabolized mainly by CYP2C19 to meprobamate. Triclabendazole and its metabolites may inhibit CYP2C19, which could raise carisoprodol exposure and sedation. The effect is short-lived because triclabendazole is given for only one or two doses.
What this interaction means in plain words
Carisoprodol and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carisoprodol belongs to Musculoskeletal; Triclabendazole belongs to Anti Parasitic.
Why it happens
Possible inhibition of CYP2C19-mediated carisoprodol metabolism by triclabendazole, an inference from in vitro data and labeling.
What to do
Monitor for increased drowsiness and dizziness during and shortly after triclabendazole treatment. Consider holding or lowering carisoprodol during the treatment course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Carisoprodol and Triclabendazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Carisoprodol
Other interactions of Triclabendazole
Frequently asked questions
Can I take Carisoprodol with Triclabendazole?
MediHelp rates the interaction as moderate. Carisoprodol and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carisoprodol is metabolized mainly by CYP2C19 to meprobamate. Triclabendazole and its metabolites may inhibit CYP2C19, which could raise carisoprodol exposure and sedation. The effect is short-lived because triclabendazole is given for only one or two doses.
How serious is the interaction between Carisoprodol and Triclabendazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased drowsiness and dizziness during and shortly after triclabendazole treatment. Consider holding or lowering carisoprodol during the treatment course.
What other medicines interact with Carisoprodol?
MediHelp also lists interactions of Carisoprodol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Carisoprodol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
