Drug interactions
Carvedilol + Ceritinib
Severity: Moderate
Carvedilol and Ceritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol inhibits P-glycoprotein and may raise ceritinib exposure modestly. Ceritinib itself can cause bradycardia and QT prolongation, which overlap with the beta-blocker's heart rate effects.
What this interaction means in plain words
Carvedilol and Ceritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Ceritinib belongs to Oncology.
Why it happens
Carvedilol inhibits P-gp efflux of ceritinib; ceritinib's bradycardic effect is also additive with beta blockade.
What to do
Monitor heart rate, blood pressure and ECG for QT interval. Reduce or stop the combination if symptomatic bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Carvedilol with Ceritinib?
MediHelp rates the interaction as moderate. Carvedilol and Ceritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carvedilol inhibits P-glycoprotein and may raise ceritinib exposure modestly. Ceritinib itself can cause bradycardia and QT prolongation, which overlap with the beta-blocker's heart rate effects.
How serious is the interaction between Carvedilol and Ceritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG for QT interval. Reduce or stop the combination if symptomatic bradycardia occurs.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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