Drug interactions
Carvedilol + Chloroquine
Severity: Moderate
Carvedilol and Chloroquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine inhibits CYP2D6, the main pathway for carvedilol metabolism, which may increase carvedilol exposure. This can cause more bradycardia, hypotension and dizziness.
What this interaction means in plain words
Carvedilol and Chloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Chloroquine belongs to Anti Parasitic.
Why it happens
Chloroquine inhibits CYP2D6-mediated metabolism of carvedilol.
What to do
Monitor heart rate and blood pressure when starting or stopping chloroquine and reduce the carvedilol dose if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Chloroquine?
MediHelp rates the interaction as moderate. Carvedilol and Chloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloroquine inhibits CYP2D6, the main pathway for carvedilol metabolism, which may increase carvedilol exposure. This can cause more bradycardia, hypotension and dizziness.
How serious is the interaction between Carvedilol and Chloroquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting or stopping chloroquine and reduce the carvedilol dose if symptomatic.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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