Drug interactions
Carvedilol + Digoxin
Severity: Moderate
Carvedilol and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol raises digoxin concentrations and both slow AV conduction. Digoxin toxicity and bradycardia or heart block may occur.
What this interaction means in plain words
Carvedilol and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Digoxin belongs to Cardiovascular.
Why it happens
Carvedilol inhibits P-glycoprotein, reducing digoxin clearance, with additive AV nodal slowing.
What to do
Monitor digoxin concentrations, heart rate and ECG, and reduce the digoxin dose if levels rise or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Carvedilol with Digoxin?
MediHelp rates the interaction as moderate. Carvedilol and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carvedilol raises digoxin concentrations and both slow AV conduction. Digoxin toxicity and bradycardia or heart block may occur.
How serious is the interaction between Carvedilol and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin concentrations, heart rate and ECG, and reduce the digoxin dose if levels rise or bradycardia occurs.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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