Drug interactions
Carvedilol + Dihydroergotamine
Severity: Moderate
Carvedilol and Dihydroergotamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dihydroergotamine causes peripheral vasoconstriction, while beta-blockers such as carvedilol can leave alpha-mediated vasoconstriction unopposed in the periphery. Together they may reduce peripheral blood flow and cause cold extremities or, rarely, worsen vasospastic ischemia.
What this interaction means in plain words
Carvedilol and Dihydroergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Dihydroergotamine belongs to Central Nervous System.
Why it happens
Pharmacodynamic opposition: ergot-induced vasoconstriction combined with beta-blockade reducing peripheral vasodilation.
What to do
Monitor for cold extremities, numbness, or pain suggesting peripheral ischemia, and stop dihydroergotamine if these appear. Carvedilol also has alpha-1 blocking activity which may partly offset the effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Carvedilol with Dihydroergotamine?
MediHelp rates the interaction as moderate. Carvedilol and Dihydroergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dihydroergotamine causes peripheral vasoconstriction, while beta-blockers such as carvedilol can leave alpha-mediated vasoconstriction unopposed in the periphery. Together they may reduce peripheral blood flow and cause cold extremities or, rarely, worsen vasospastic ischemia.
How serious is the interaction between Carvedilol and Dihydroergotamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cold extremities, numbness, or pain suggesting peripheral ischemia, and stop dihydroergotamine if these appear. Carvedilol also has alpha-1 blocking activity which may partly offset the effect.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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