Drug interactions
Carvedilol + Fedratinib
Severity: Moderate
Carvedilol and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate inhibitor of CYP2D6, which is a main route of carvedilol clearance. Exposure to the more potent R(+) enantiomer of carvedilol may rise, increasing the risk of bradycardia, hypotension and dizziness.
What this interaction means in plain words
Carvedilol and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Fedratinib belongs to Oncology.
Why it happens
Fedratinib inhibits CYP2D6-mediated oxidative metabolism of carvedilol.
What to do
Monitor heart rate and blood pressure when fedratinib is started or stopped. Reduce the carvedilol dose if bradycardia or symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Carvedilol with Fedratinib?
MediHelp rates the interaction as moderate. Carvedilol and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate inhibitor of CYP2D6, which is a main route of carvedilol clearance. Exposure to the more potent R(+) enantiomer of carvedilol may rise, increasing the risk of bradycardia, hypotension and dizziness.
How serious is the interaction between Carvedilol and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when fedratinib is started or stopped. Reduce the carvedilol dose if bradycardia or symptomatic hypotension develops.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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