Drug interactions
Carvedilol + Fluconazole
Severity: Minor
Carvedilol and Fluconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole may increase exposure to the more active S-enantiomer of carvedilol. This can lead to more bradycardia, hypotension and dizziness.
What this interaction means in plain words
Carvedilol and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carvedilol belongs to Cardiovascular; Fluconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP2C9 (and CYP2D6/3A4 contributions) metabolism of carvedilol.
What to do
Monitor heart rate and blood pressure when fluconazole is started or stopped. Reduce carvedilol dose if symptomatic bradycardia or hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Fluconazole?
MediHelp rates the interaction as minor. Carvedilol and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluconazole may increase exposure to the more active S-enantiomer of carvedilol. This can lead to more bradycardia, hypotension and dizziness.
How serious is the interaction between Carvedilol and Fluconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when fluconazole is started or stopped. Reduce carvedilol dose if symptomatic bradycardia or hypotension occurs.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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