Drug interactions
Carvedilol + Fostamatinib
Severity: Moderate
Carvedilol and Fostamatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite tamatinib inhibits P-glycoprotein, and carvedilol is a P-gp substrate. Carvedilol concentrations may increase, which may lead to bradycardia, hypotension or dizziness.
What this interaction means in plain words
Carvedilol and Fostamatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Fostamatinib belongs to Oncology.
Why it happens
Tamatinib inhibits intestinal P-glycoprotein efflux of carvedilol, increasing its absorption.
What to do
Monitor heart rate and blood pressure when starting fostamatinib. Lower the carvedilol dose if excessive beta-blockade occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Carvedilol with Fostamatinib?
MediHelp rates the interaction as moderate. Carvedilol and Fostamatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostamatinib's active metabolite tamatinib inhibits P-glycoprotein, and carvedilol is a P-gp substrate. Carvedilol concentrations may increase, which may lead to bradycardia, hypotension or dizziness.
How serious is the interaction between Carvedilol and Fostamatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting fostamatinib. Lower the carvedilol dose if excessive beta-blockade occurs.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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