Drug interactions
Carvedilol + Levoketoconazole
Severity: Moderate
Carvedilol and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole inhibits CYP3A4 and may inhibit other enzymes, including CYP2C9 and possibly CYP2D6. Carvedilol exposure may increase modestly, leading to bradycardia or hypotension. Levoketoconazole also prolongs the QT interval, which is a separate concern in cardiac patients.
What this interaction means in plain words
Carvedilol and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Levoketoconazole belongs to Endocrine.
Why it happens
Levoketoconazole inhibits CYP-mediated metabolism of carvedilol, and may inhibit P-gp.
What to do
Monitor heart rate and blood pressure when starting or stopping levoketoconazole. Adjust the carvedilol dose if excessive beta-blockade develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Carvedilol with Levoketoconazole?
MediHelp rates the interaction as moderate. Carvedilol and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole inhibits CYP3A4 and may inhibit other enzymes, including CYP2C9 and possibly CYP2D6. Carvedilol exposure may increase modestly, leading to bradycardia or hypotension. Levoketoconazole also prolongs the QT interval, which is a separate concern in cardiac patients.
How serious is the interaction between Carvedilol and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting or stopping levoketoconazole. Adjust the carvedilol dose if excessive beta-blockade develops.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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