Drug interactions
Avanafil + Levoketoconazole
Severity: Contraindicated
Avanafil and Levoketoconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole strongly inhibits CYP3A4 and is expected to markedly increase avanafil concentrations. Severe hypotension, syncope, visual disturbances and priapism may occur.
What this interaction means in plain words
Avanafil and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Avanafil belongs to Genitourinary; Levoketoconazole belongs to Endocrine.
Why it happens
Strong CYP3A4 inhibition reduces avanafil clearance.
What to do
Do not coadminister. Use a non-interacting treatment for erectile dysfunction during levoketoconazole therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
- Colchicine + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Avanafil with Levoketoconazole?
MediHelp rates the interaction as contraindicated. Avanafil and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levoketoconazole strongly inhibits CYP3A4 and is expected to markedly increase avanafil concentrations. Severe hypotension, syncope, visual disturbances and priapism may occur.
How serious is the interaction between Avanafil and Levoketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Use a non-interacting treatment for erectile dysfunction during levoketoconazole therapy.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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