Drug interactions
Cisapride + Levoketoconazole
Severity: Contraindicated
Cisapride and Levoketoconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole strongly inhibits CYP3A4 and itself prolongs the QT interval. Cisapride concentrations rise and the risk of torsades de pointes and cardiac arrest increases substantially.
What this interaction means in plain words
Cisapride and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cisapride belongs to Gastrointestinal Tract; Levoketoconazole belongs to Endocrine.
Why it happens
Strong CYP3A4 inhibition reduces cisapride metabolism, combined with additive QT prolongation.
What to do
Do not coadminister; use an alternative prokinetic during levoketoconazole therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Cisapride
- Apomorphine + Cisapride Contraindicated
- Artemether + Cisapride Contraindicated
- Azithromycin + Cisapride Contraindicated
- Ceritinib + Cisapride Contraindicated
- Chloroquine + Cisapride Contraindicated
- Cisapride + Citalopram Contraindicated
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
- Colchicine + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Cisapride with Levoketoconazole?
MediHelp rates the interaction as contraindicated. Cisapride and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levoketoconazole strongly inhibits CYP3A4 and itself prolongs the QT interval. Cisapride concentrations rise and the risk of torsades de pointes and cardiac arrest increases substantially.
How serious is the interaction between Cisapride and Levoketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative prokinetic during levoketoconazole therapy.
What other medicines interact with Cisapride?
MediHelp also lists interactions of Cisapride with, for example, Apomorphine, Artemether, Azithromycin. The full list is on the Cisapride page.
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